Fig. 8

Schematic diagram of the molecular mechanism of circPVT1 promoted NPC metastasis. Circular RNA circPVT1 interacts with β-TrCP to prevent β-TrCP-induced c-Myc ubiquitination and degradation, which results in enhanced migration and invasion of NPC cells. Oncoprotein c-Myc promotes circPVT1 transcription through binding to the promoter region of PVT1 gene, and recruits the splicing factor SRSF1 to facilitate circPVT1 splicing, which forms a positive feedback loop that promotes the migration and invasion of NPC cells