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Fig. 2 | Molecular Cancer

Fig. 2

From: Improving cancer immunotherapy by rationally combining oncolytic virus with modulators targeting key signaling pathways

Fig. 2

The Effects of small-molecule drugs on the TME. Targeted therapies have been shown to alter the TME in multiple ways, either directly or indirectly. Some agents could reverse the immunosuppressive environment by inhibiting the infiltration and function of MDSCs and Tregs. Numerous therapies increase the expression and presentation of tumor antigens, increasing cross-priming of DCs for enhanced T cell activation. Targeted therapies also can increase the expression of NKG2D ligands on NK cells, which serve as co-stimulatory molecules for CTL,as well as activators of NK cells, which also increase the NK cytotoxicity

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Molecular Cancer

ISSN: 1476-4598