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Fig. 1 | Molecular Cancer

Fig. 1

From: The single cell transcriptional landscape of esophageal adenocarcinoma and its modulation by neoadjuvant chemotherapy

Fig. 1

High level cell type ATLAS of Esophageal Adenocarcinoma. A UMAP embedding overlaid with unsupervised cluster cell type annotations (left) and sample label (right). B Proportional sample contributions to each cell type cluster. C UMAP embeddings split by treatment and tissue type. D Breakdown of cluster proportions by sample, chemotherapy treatment and tissue type. Grey line indicates matched tumor and Adjacent Normal (AN) samples. E UMAP embeddings overlaid with expression of canonical high level cell type marker genes. F Average expression profile of top cluster marker genes. Dot size indicates the percentage of the cluster showing expression G Comparison by Mann-Whitney test of Adjacent Normal (AN) vs Tumor (T) and pre vs post chemotherapy cluster proportions. H Cluster proportions by Mandard scores. Points represent within-sample cluster proportion of total cells and p values determined by Mann-Whitney test

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Molecular Cancer

ISSN: 1476-4598