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Fig. 3 | Molecular Cancer

Fig. 3

From: The single cell transcriptional landscape of esophageal adenocarcinoma and its modulation by neoadjuvant chemotherapy

Fig. 3

NACT modulation of Myeloid cell contexture identifies shift in cDC:pDC ratio within the tumor microenvironment of Esophageal Adenocarcinoma. A UMAP embedding overlaid with cluster cell type annotations and UMAP embeddings split by treatment and tissue type. B UMAP embeddings overlaid with expression of canonical Myeloid cell type marker genes. C Average expression profile of top cluster marker genes. D Breakdown of cluster proportions by sample, chemotherapy treatment and tissue type. E Comparison by Mann-Whitney test of Adjacent Normal (AN) vs Tumor (T), pre vs post chemotherapy and Mandard score cluster proportions. Points represent within sample cluster proportion of total sample Myeloid cells. F cDC:pDC ratios stratified by tissue type and chemotherapy. P values determined by Mann-Whitney test

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Molecular Cancer

ISSN: 1476-4598