Table 3 Multispecific CAR-T cell therapy in solid tumors

HCC

CD70/B7H3

[189, 414, 432,433,434]

GPC3/CD147

c-MET/PD-L1

GPC3/ASGR1

gp100/HER2

Glioma

CD70/B7H3

[189, 374,375,376, 435, 436]

HER2/IL13Rα2

EGFRvIII/IL13Rα2 OR EphA2; MOG/IL13Rα2 OR EphA2

EGFRvIII/IL13Rα2 OR CD133

HER2/IL13Rα2/EphA2

IL13Rα2/ EphA2

GC

Trop2/PD-L1

[277]

PC

MSLN/CEA

[437, 438]

MSLN/PSMA

EC

CD70/B7H3

[189]

CRC

CD30/CEA;

CD30/TAG70

[439]

BC

CD70/B7H3

[189, 414, 440,441,442]

Her2/IGF1R

MUC1/HER2

ROR1/B7H3

gp100/HER2

PCa

MSLN/PSMA

[437]

LCa

CD70/B7H3

[189, 204, 442]

ROR1/B7H3

PSCA/MUC1

OC

FLOR1/MSLN

[330, 333, 334]

ALPPL2/MCAM

ALPPL2/MSLN

ALPPL2/HER2

PD-L1/MUC16

MEL

CD70/B7H3

gp100/CSPG4

gp100/VEGFR-2

[189, 314, 443]