Table 2 Factors that regulate exosome biogenesis
From: Exosome biogenesis: machinery, regulation, and therapeutic implications in cancer
| Â | Genes | Roles on exosome biogenesis | Targets | Cancer cell types | Refs |
|---|---|---|---|---|---|
microRNAs | Let-7a | Inhibit | SNAP23 | CRC | [196] |
miR-134 and miR -135b | Inhibit | YKT6 | NSCLC | [195] | |
LncRNAs | LncRNA-APC1 | Inhibit | Rab5b | CRC | [198] |
LINC00511 | Enhance | RAB27B, VAMP7-SNAP23 complex | HCC | [127] | |
PVT1 | Enhance | YKT6, RAB7, and VAMP3 | Pancreatic cancer | [199] | |
HOTAIR | Enhance | Rab35, SNAP23 | HCC | [135] | |
PTMs | Phosphorylation | Enhance | Syntenin, SNAP23, Hrs | Breast cancer, melanoma | |
Inhibit | Ago2 | Colon cancer | [181] | ||
SUMOylation | Enhance | hnRNPA1, hnRNPA2B1 | Bladder cancer | ||
O-GlcNAclation | Inhibit | SNAP-23 | Ovarian and Breast cancer | [141] | |
Neddylation | Inhibit | Coro1a | Colon cancer | [102] |