Skip to main content
Fig. 9 | Molecular Cancer

Fig. 9

From: Long noncoding RNA DLGAP1-AS2 promotes tumorigenesis and metastasis by regulating the Trim21/ELOA/LHPP axis in colorectal cancer

Fig. 9

CPSF2 and CSTF3 increase the stability of DLGAP1-AS2 in CRC cells. A The effects of CPSF2 or CSTF3 on DLGAP1-AS2 expression. B The effect of CPSF2 or CSTF3 on the half-life of DLGAP1-AS2 in CRC cells treated with actinomycin D (2ug/ml). C The effect of CPSF2 or CSTF3 on the expression of ELOA and AKT pathway (pAKT at Ser473). D The interaction between CPSF2 and CSTF3 was evaluated using IP assays. E DLGAP1-AS2 promoted the interaction between CPSF2 and CSTF3. F The effect of CPSF2 and CSTF3 overexpression on the expression of DLGAP1-AS2. DLGAP1-AS2 mutation (ΔAATAAA) inhibited CPSF2 and CSTF3-induced upregulation of DLGAP1-AS2 levels in HCT116 cells. G Integrated model depicting the tumor-promoting effect and molecular mechanism of DLGAP1-AS2 in CRC

Back to article page

Molecular Cancer

ISSN: 1476-4598