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Fig. 6 | Molecular Cancer

Fig. 6

From: Single low-dose INC280-loaded theranostic nanoparticles achieve multirooted delivery for MET-targeted primary and liver metastatic NSCLC

Fig. 6

Clinical translational potential of INC280-PFCE NPs. A Ex vivo experiment with PDTFs. Freshly surgically resected lung cancer tissues were divided into 9 fragments, each of which was 40 ~ 50 mm3 in size, and randomly cultured in medium with PBS, INC280 or INC280-PFCE NPs for 48 h. The groups of INC280 and INC280-PFCE NPs had the same concentration of INC280 (10 nM). B Representative computed tomography (CT) images of a 68-year-old aging patient diagnosed with NSCLC (red arrow, tumor). C-D After the PDTFs were processed for 48 h, the expression of total MET and phospho-MET was verified and quantified by western blot. GAPDH was selected as the internal control. E Histopathological analysis (H&E staining and IHC assay) of the PDTFs after 48 h of ex vivo targeted therapy. Scale bar = 100 µm. Data are presented as mean ± standard deviation (n = 6). * P < 0.05

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Molecular Cancer

ISSN: 1476-4598