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Fig. 3 | Molecular Cancer

Fig. 3

From: Tumor microenvironment enriches the stemness features: the architectural event of therapy resistance and metastasis

Fig. 3

The tumor microenvironment and their cross-talk signal mechanisms in immune cells, inflammatory cells, endothelial cells, adipocytes, and fibroblasts drive the cancer stem cell maintenance: The schematic illustration summarizes the microenvironmental tumor factors secreting signaling molecules’ role in the CSC maintenance. Abbreviations: MFG-E8-Milk fat globule-EGF factor 8 protein; EMT-Epithelial-mesenchymal transition; MMP 9-Matrix metallopeptidase 9; TGF-β- Transforming growth factor-β; CCL5- C-C motif chemokine ligand 5; ICAM1-Intercellular adhesion molecule 1; IFNs-Interferons; TNF-α-Tumor necrosis factor-α; IL 6- Interleukin 6; ALDH1-Aldehyde dehydrogenase 1; DNMT1-DNA methyltransferase 1; CtBP2-C-terminal-binding protein 2 ; MIF-Macrophage migration inhibitory factor

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Molecular Cancer

ISSN: 1476-4598