Table 2 List of clinical trials ongoing tumor microenvironment and cancer stem cells-related targeted drugs treatment
Drugs | Cancer | NCT No. | Status | References |
|---|---|---|---|---|
MK-3475 (Pembrolizumab) | Triple negative breast cancer (TNBC) | NCT02977468 | Recruiting | [222] |
MK-3475 (Pembrolizumab) | Metastatic melanoma | NCT03534635 | Recruiting | [223] |
Mifamurtide | Osteosarcoma | NCT03737435 | Unknown | [224] |
ALKS 4230 Pembrolizumab | Solid Tumor Patients | NCT04592653 | Recruiting | [225] |
Abemaciclib Nivolumab | Head and Neck Cancer | NCT04169074 | Not yet recruiting | |
Gadobutrol [F-18] HX4 Gemcitabine | Pancreatic Cancer | NCT01989000 | Completed | [228] |
Avelumab CTX | Head and Neck Cancer | NCT03844763 | Recruiting | [229] |
Dacarbazine | Melanoma | NCT04225390 | Not yet recruiting | [230] |
Plerixafor | Pancreatic Cancer | NCT03954691 | Not yet recruiting | [231] |
bevacizumab | Breast Cancer | NCT01190345 | Completed | [232] |
Metformin | Ovarian Cancer | NCT01579812 | Completed | [233] |
Etoposide Atezolizumab | Small Cell Lung Cancer | NCT05055999 | Completed | [234] |
Liposomal Doxorubicin Docetaxel Paclitaxel Carboplatin Cisplatin Gemcitabine Topotecan | Ovarian Cancer | NCT03949283 | Recruiting | [235] |
Carboplatin Irinotecan Etoposide Carmustine (BCNU) Lomustine (CCNU) Temozolomide Procarbazine Vincristine Imatinib | Glioblastoma | NCT03632135 | Active, Not yet recruiting | [236] |