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Fig. 4 | Molecular Cancer

Fig. 4

From: circCYP24A1 facilitates esophageal squamous cell carcinoma progression through binding PKM2 to regulate NF-κB-induced CCL5 secretion

Fig. 4

CCL5 is functional downstream mediator for circCYP24A1. a 484 changed genes in KYSE150 cells treated with si-circCYP24A1 were identified by Agilent microarray. The screening criteria were the fold change value of up-regulation or down-regulation < 2 and the P value < 0.05. b Enrichment analysis for representative GO_BP and KEGG pathways in circCYP24A1 target genes. c Relative expression levels of representative genes in KYSE150 cells treated with si-circCYP24A1. d Relative expression levels of representative genes in TE1 cells transfected with circCYP24A1. e ELISA measured the levels of CCL5 in the supernatants of KYSE30 cells upper) and KYSE150 (lower) with circCYP24A1 overexpression. f ELISA measured the levels of CCL5 in the supernatants of KYSE170 cells (upper) and TE1 (lower) with circCYP24A1 knockdown. △P > 0.05, *P < 0.05,**P < 0.01, ***P < 0.001

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Molecular Cancer

ISSN: 1476-4598