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Fig. 6 | Molecular Cancer

Fig. 6

From: circCYP24A1 facilitates esophageal squamous cell carcinoma progression through binding PKM2 to regulate NF-κB-induced CCL5 secretion

Fig. 6

circCYP24A1 interacts with PKM2 and promotes NF-κB pathway-mediated CCL5 secretion in vitro. a Binding of CYP24A1 with PKM2 was idntified by RNA pull-down-western blot analysis. b The co-localization of circCYP24A1 (red) with PKM2 (green) in KYSE30 and TE1 cells was idntified by RNA FISH-immunofluorescence. c Protein levels in ESCC cells with circCYP24A1 overexpression or PKM2 knockdown. d mRNA and protein levels of CCL5 in ESCC cells with circCYP24A1 overexpression or PKM2 knockdown. e The proliferation ability of ESCC cells with circCYP24A1 overexpression or PKM2 knockdown was detected by CCK-8 assays. f The migration and invasion abilities of ESCC cells with circCYP24A1 overexpression or PKM2 knockdown were detected by transwell migration and matrigel invasion assay. *P < 0.05, **P < 0.01, ***P < 0.001

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Molecular Cancer

ISSN: 1476-4598