Fig. 5
From: CircNTNG1 inhibits renal cell carcinoma progression via HOXA5-mediated epigenetic silencing of Slug
HOXA5 is a unique tumor suppressor for RCC among HOXA family. a. Survival profiling of the HOXA family of the KIRC, KIRP and KICH datasets from TCGA. Solid border outline indicates significant survival gene. HR, hazard ratio; FDR, false discovery rate. b. Expression analysis of HOXA5 in 72 pairs of match tumors and normal adjacent tissues from KIRC. c. Survival analysis (overall survival) of HOXA5 in TCGA KIRC dataset. d. Expression analysis of HOXA5 in tumors and normal adjacent tissues in our patient cohort (total 102 patients). e. Survival analysis (overall survival) of HOXA5 in our patient cohort. f. Genomic alteration rate of HOXA5 and several other frequently mutated genes in five different datasets (DFCI, BGI, IRC, TCGA, and UTokyo). Data was obtained from cBioPortal website. g. Immunoblotting analysis of HOXA5 protein expression in 8 pairs of fresh tumors and normal adjacent tissues. GAPDH was used as positive control. h. Representative images of HOXA5 IHC staining in patients with different clinical stages (left) and quantification of IHC scores (right)