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Fig. 5 | Molecular Cancer

Fig. 5

From: MicroRNA-1 attenuates the growth and metastasis of small cell lung cancer through CXCR4/FOXM1/RRM2 axis

Fig. 5

miR-1 modulates the CXCR4/FOXM1/RRM2 axis in SCLC. Heatmap of top differentially expressed genes from (A) miR-1(-DOX-Off) and + miR-1 (+ DOX-On) SBC5 cells, (B) SBC3 and SBC3-miR-1Zip cells. C-D Clustering and gene interaction network analysis (http://string-db.org/) of top differentially expressed genes from RNA-Seq analysis of miR-1 sponging and overexpression models. E Heatmap for normalized expression of CXCR4, FOXM1, and RRM2 in a panel of NCI SCLC cell lines data sets (https://discover.nci.nih.gov/rsconnect/SclcCellMinerCDB/). F Cell surface expression analysis of CXCR4 in SBC3, SBC3-miR-1Zip, SBC5, and NCI-H69 cells under no miR-1(-DOX-Off) and + miR-1 (+ DOX-On) conditions through FACS analysis

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Molecular Cancer

ISSN: 1476-4598