From: Targeting SOST using a small-molecule compound retards breast cancer bone metastasis
 | Univariate analysis | Multivariate analysis | ||
---|---|---|---|---|
Hazard ratio (95% CI) | P-value | Hazard ratio (95% CI) | P-value | |
SOST × menopause status | 2.59 (1.80–3.73) |  < 0.001 | 2.12 (1.46–3.08) |  < 0.001 |
T stage | Â | 0.660 | Â | 0.917 |
 T2 vs. T1 | 1.02 (0.71–1.46) | 0.926 | 1.00 (0.68–1.47) | 0.988 |
 T3 vs. T1 | 1.44 (0.65–3.21) | 0.374 | 1.19 (0.51–2.79) | 0.696 |
N stage | 4.38 (3.16–6.06) |  < 0.001 | 4.15 (2.94–5.88) |  < 0.001 |
ER × PR | 0.60 (0.43–0.83) | 0.002 | 0.54 (0.35–0.82) | 0.004 |
HER2 | 0.99 (0.72–1.38) | 0.969 | 0.66 (0.38–1.16) | 0.150 |
Ki67 | 0.98 (0.71–1.34) | 0.877 | 0.98 (0.69–1.39 | 0.895 |
Molecular type | Â | 0.910 | Â | 0.331 |
 HR + HER2 +  |  |  |  |  |
 vs. HR + HER2- | 0.90 (0.59–1.38) | 0.645 | 0.68 (0.43–1.08) | 0.103 |
 HR-HER2 +  |  |  |  |  |
 vs. HR + HER2- | 1.09 (0.70–1.69) | 0.706 | 0.66 (0.38–1.16) | 0.150 |
 TNBC |  |  |  |  |
 vs. HR + HER2- | 0.96 (0.60–1.56) | 0.879 | 0.82 (0.45–1.48) | 0.503 |