Fig. 2

Biomarker validation phase of 10-miRNA classifier for predicting response to FOLFOX-based adjuvant chemotherapy in primary tumors or matched pre-surgery serums from CRC patients of the independent cohort. A ROC curve values for 10-miRNA classifier for predicting response to FOLFOX in tissue- and serum-based validation cohort (AUC = 0.83 and 0.79, respectively). B Box plot of tissue-based 10-miRNA classifier score for predicting response to FOLFOX in CRC patients. C Box plot of serum-based 10-miRNA classifier score for predicting response to FOLFOX in CRC patients. D ROC curve values for the combination of tissue- and serum-based 10-miRNA classifier for predicting response to FOLFOX (AUC = 0.89). E Forest plot with AUC of combined or tissue-based or serum-based 10-miRNA classifier for predicting response to FOLFOX in CRC patients. F Waterfall plot with combined 10-miRNA classifier score for predicting response to FOLFOX in CRC patients. G Kaplan-Meier curves of the recurrence-free survival for patients with combined 10-miRNA classifier high (n = 19) or low (n = 58). CRC, colorectal cancer; ROC, Receiver operating characteristics; AUC, area under the curve; HR, hazard ratio; CI, confidence interval