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Fig. 3 | Molecular Cancer

Fig. 3

From: lncRNA ZNRD1-AS1 promotes malignant lung cell proliferation, migration, and angiogenesis via the miR-942/TNS1 axis and is positively regulated by the m6A reader YTHDC2

Fig. 3

ZNRD1-AS1 knockdown promotes lung cancer cell proliferation. A Enrichment analysis of the predicted ceRNAs of ZNRD1-AS1 based on the StarBase online tool. CCK-8 experiments analyzed the proliferation ability of cells following ZNRD-AS1 overexpression or knockdown in (B) S30 cells and (C) H1299 cells. ** P < 0.01 vs. pCDH blank or shNC. Representative images and quantitative results of the cell cycle following knockdown or overexpression of YTHDC2 in (D and E) S30 cells and (F-G) H1299 cells. The EdU cell proliferation assay was used to determine cell proliferation ability following knockdown or overexpression of YTHDC2 in (H) S30 and (I) H1299 cells. ** P < 0.01 and *** P < 0.001 vs. pCDH blank, and # P < 0.05 and ## P < 0.01 vs. shNC. shNC: the blank pGreen vector for knockdown

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Molecular Cancer

ISSN: 1476-4598