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Fig. 4 | Molecular Cancer

Fig. 4

From: lncRNA ZNRD1-AS1 promotes malignant lung cell proliferation, migration, and angiogenesis via the miR-942/TNS1 axis and is positively regulated by the m6A reader YTHDC2

Fig. 4

YTHDC2 downregulation promotes lung cancer cell migration and angiogenesis. Representative images and quantitative results of the Transwell migration assay for (A) S30 and (B) H1299 cells with knockdown or overexpression of ZNRD1-AS1. C Representative images and quantitative results for the wound healing assay for (C) S30 and (D) H1299 cells. RT-qPCR analysis of CDH1 and CDH2 mRNA expression levels in ZNRD1-AS1 (E) overexpressed and (F) knockdown S30 and H1299 cells. G-I Protein expression and quantification results of CDH1 and CDH2 in S30 and H1299 cells were determined using western blotting. * P < 0.05 and ** P < 0.01 vs. pCDH blank or pGreen blank. The HUVEC tube formation assay analyzed the alteration of proangiogenic ability following the overexpression or knockdown of ZNRD1-AS1 in (J) S30 and (K) H1299 cells. ## P < 0.01 vs. pGreen blank. CDH1: E-cadherin. CDH2: N-cadherin. shNC: the blank pGreen vector for knockdown

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Molecular Cancer

ISSN: 1476-4598