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Fig. 5 | Molecular Cancer

Fig. 5

From: lncRNA ZNRD1-AS1 promotes malignant lung cell proliferation, migration, and angiogenesis via the miR-942/TNS1 axis and is positively regulated by the m6A reader YTHDC2

Fig. 5

ZNRD1-AS1 overexpression suppresses H1299 cell proliferation in vivo. A Images of the xenograft tumors formed in nude mice that were injected with ZNRD1-AS1-overexpressing cells or control cells. The (B) volume and (C) weight of the xenograft tumors isolated from nude mice. E Representative images and the (F) quantified result of the EdU cell proliferation assay for single cell suspensions yielded from xenograft tumors. G Representative images of H&E staining and the IHC staining of ZNRD1-AS1, Ki-67, cyclin D1, CDH1 and CDH2 in the xenograft tumors derived from nude mice. Scale bar = 100 μm. H Average optical density results of CDH1 and CDH2 were quantified using the ImageJ plugin IHC profiler. I The percentage of Ki67 and cyclin D1 positive cells was quantified using ImageJ. J The blood vessel area of tumor tissue was quantified using ImageJ. **P < 0.01 vs. blank group. IHC: immunohistochemical. CDH1: E-cadherin. CDH2: N-cadherin

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Molecular Cancer

ISSN: 1476-4598