Table 2 Latest investigations on inorganic NPs-based therapeutic approaches for skin cancer
From: Advancements in nanoparticle-based treatment approaches for skin cancer therapy
Type | Therapeutic agent | Particle size | In vitro cytotoxicity study | Animal model | Route of administration | Ref |
|---|---|---|---|---|---|---|
Mesoporous silica nanoparticles | Stimulator of interferon genes (STING) | 80 nm (particle size)/ 5–10 nm (pore size) | Mice melanoma cell line (B16F10) | Melanoma-bearing C57BL/6 mice | Intratumoral | [216] |
Mesoporous silica nanoparticles | JQ-1 (immunotherapy)/ Polydopamine (PTT) | 174.0 ± 2.4 nm | Mice melanoma cell line (B16F10) | Melanoma-bearing male C57BL/6 mice | Intratumoral | [217] |
Mesoporous silica nanoparticles | Axitinib/ sgPD-L1/ CRISPR/Cas9 | 135 ± 8.7 nm | Mice melanoma cell line (B16F10) | Melanoma-bearing female C57BL/6 mice | Intravenous | [218] |
Carbon nanotubes | Multiwalled carbon nanotubes (PTT) | 3–15 nm (walls)/ 5–20 nm (outer diameter)/ 1–10 µm (length) | Mice melanoma cell line (B16F10) | Melanoma-bearing female C57BL/6 J mice | Intravenous | [219] |
Carbon nanotubes | Multiwalled carbon nanotubes (Nanocyl™ NC3100) | 9.5 nm (diameter)/ 1.5 µm (length) | Mice melanoma cell line (B16F10) | Mice | Intratumoral | [220] |
Carbon nanotubes | Cytosine-phosphate-guanine oligodeoxynucleotide/ Anti-CD40 Ig/ Ovalbumin | 20–30 nm (diameter)/ 0.5–2 µm (length) | - | Melanoma-bearing C57BL/6 mice | Intravenous | [221] |
Zinc oxide nanoparticles | Zinc oxide nanoparticles | 154.41–172.89 nm | Human epidermoid carcinoma cell line (A431)/ Human keratinocyte cell line (HaCaT) | - | - | [222] |
Zinc oxide nanoparticles | Zinc oxide nanoparticles | 10–20 nm | Human melanoma cell line (A375) | - | - | [223] |
Zinc oxide nanoparticles | Zinc oxide nanoparticles | 50 nm | Human epidermoid carcinoma cell line (A431) | - | - | [224] |
Gold nanoparticles | Gold nanoparticles/ HuAL1 and C7H2 peptides | 270 ± 22 nm | Mice melanoma cell line (B16F10)/ Human foreskin fibroblast cell line (Hs68) | Melanoma-bearing C57BL/6 mice | - | [225] |
Gold nanoparticles | Gold nanoparticles (PTT) | 157 ± 5 nm | Mice melanoma cell line (B16F10) | Melanoma-bearing severe combined immunodeficient (SCID) hairless mice (Xenograft-A375) | Intratumoral | [226] |
Gold nanoparticles | Gold-iron oxide nanoparticles | 37.8 nm | - | Melanoma-bearing C57BL/6 mice | Intravenous | [227] |
Gold nanoparticles | Cytosine-guanine oligodeoxynucleotide/ CSIINFEKL (peptide-based tumor antigen vaccine) | 146.30 ± 1.93 nm | - | Melanoma-bearing female C57BL/6 mice | Intravenous | [228] |
Silver nanoparticles | Silver nanoparticles (PTT) | 100 nm | Mice melanoma cell line (B16F10) | Melanoma-bearing athymic nude mice | Topical | [229] |
Silver nanoparticles | Silver nanoparticles | 35 ± 15 nm | Mice melanoma cell line (B16F10) | Melanoma-bearing male C57BL/6 J mice | Subcutaneous | [230] |
Silver nanoparticles | Silver nanoparticles/ Salmonella | 15 nm | Mice melanoma cell line (B16F10) | Melanoma-bearing BALB/c mice | Intravenous | [231] |
Silver nanoparticles | Silver nanoparticles/ Indocyanine green (PTT) | 131.5 ± 2.7 nm | Mice melanoma cell line (B16F10) | Melanoma-bearing athymic nude mice | Intravenous | [232] |
Cerium oxide nanoparticles | Cerium oxide nanoparticles | 5 nm | Human melanoma cell line (A375) | Melanoma-bearing athymic nude mice (Xenograft-A375) | Intraperitoneal | [233] |
Platinum nanoparticles | Iron-platinum nanoparticles/ 5-Fluorouracil | 6 ± 1 nm | Human skin fibroblasts cell line/ Human basal-cell carcinoma cell line | - | Topical | [234] |
Platinum nanoparticles | Platinum nanoparticles (PTT) | 12.2 ± 0.7 nm | Mice melanoma cell line (B16F10) | - | - | [235] |
Copper nanoparticles | Copper nanoparticles | 60–80 nm | Human melanoma cell line (A375) | - | - | [236] |
Titanium dioxide nanoparticles | Titanium dioxide nanoparticles (PDT) | 20–90 nm | Mice melanoma cell line (B16F10) | - | - | [237] |
Titanium dioxide nanoparticles | Titanium dioxide nanoparticles/ Gold nanoclusters/ Graphene (PDT) | 206–384 nm | Mice melanoma cell line (B16F10) | Melanoma-bearing female BALB/c athymic nude mice | Intravenous/ Intratumoral | [238] |