Table 4 Latest investigations on lipid NPs-based therapeutic approaches for skin cancer
From: Advancements in nanoparticle-based treatment approaches for skin cancer therapy
Type | Chief composition | Therapeutic agent | Particle size and entrapment efficiency | In vitro cytotoxicity study | Animal model | Route of administration | Ref |
|---|---|---|---|---|---|---|---|
Solid lipid nanoparticles | Glyceryl monostearate/ Dimethyldioctadecyl ammonium bromide | Ascorbyl palmitate/ Paclitaxel | 223–254 nm | Mice melanoma cell line (B16F10) | Melanoma-bearing female C57BL/6 mice | Intravenous | [350] |
Solid lipid nanoparticles | Lecithin | 5-Fluorouracil | 137 ± 5.5–800 ± 53.6 nm | - | Melanoma-bearing male BALB/c mice | Topical | [351] |
Solid lipid nanoparticles | Sodium behenate/ PVA9000 | Temozolomide | 273.15 ± 5 nm | Mice melanoma cell line (B16F10) | Melanoma-bearing female C57BL/6 J mice | Topical | [352] |
Solid lipid nanoparticles | Glycerol palmitostearate | Doxorubicin | 92 ± 2 nm | Mice melanoma cell line (B16F10) | Melanoma-bearing male BALB/c mice | Topical | [353] |
Nanostructured lipid carriers | Beeswax/ Lavender oil/ Melaleuca oil | Bupivacaine | 189.6–313.9 nm (lavender)/ 204.2–414.0 nm (melaleuca) | Mice melanoma cell line (B16F10) | - | Topical | [354] |
Nanostructured lipid carriers | Lipid Sefsol®/ Geleol® | Silymarin | - | Mice melanoma cell line (B16F10) | Melanoma-bearing albino Swiss mice | Topical | [355] |
Liposomes | Dipalmitoyl phosphatidyl choline/ Cholesterol/ Cyclodextrin/ Polyethyleneimine | Ovalbumin | 207 ± 20 nm | - | Melanoma-bearing male C57BL/6 mice | - | [356] |
Liposomes | Dipalmitoyl phosphatidyl choline/ Hydrogenated soy phosphatidylcholine/ Cholesterol | Doxorubicin | 114–123 nm | - | Melanoma-bearing female C57BL/6 mice | Intravenous/ Intratumoral | [357] |
Liposomes | Hydrogenated soy phosphatidylcholine/ Cholesterol | Epacadostat | 128.1 ± 1.1 nm | Mice melanoma cell line (B16F10) | Melanoma-bearing female C57BL/6 mice | Intravenous | [358] |
Liposomes | Soybean phospholipids/ Cholesterol/ Didodecyl dimethylammonium bromide/ Tocopherol PEG 1000 succinate | MicroRNAs | 134 ± 1.42 nm | Human epidermoid carcinoma cell line (A431) | Squamous cell carcinoma-bearing BALB/c nude mice | Intravenous | [359] |
Niosomes | Span 60/ Tween 60/ Cholesterol | Ozonated olive oil | 125.34 ± 13.29 nm | Human melanoma cell line (A375) | - | Topical | [360] |
Niosomes | Span 85/ Cholesterol | Ethanol extract of propolis | 232Â nm | Human melanoma cell line (SK-MEL) | - | Topical | [361] |
Ethosomes | Ethanol/ Phospholipon 90 G/ Cholesterol | Vismodegib | 559.77–562.90 nm | - | Basal cell carcinoma-bearing male Swiss albino mice | Topical | [362] |
Ethosomes | Ethanol/ Soya lecithin/ Cholesterol | Silver nanoparticles/ Silk sericin | 261.3 ± 5.21 | Human epidermoid carcinoma cell line (A431) | Squamous cell carcinoma-bearing BALB/c mice | Topical | [363] |