Table 5 Patents published on NPs-based therapeutic approaches for skin cancer
From: Advancements in nanoparticle-based treatment approaches for skin cancer therapy
Type of nanoparticle/ Therapeutic agent | Patent no | Inventors and Applicants | Title of the invention | Type of study | Year of publication | Ref |
|---|---|---|---|---|---|---|
Organometallic complex (Iron-based) | US2010119608A1 | Fred et al | Synthesis of pH-sensitive, acid-stable metal-binding nanoparticles | In vivo | 2010 | [384] |
Cerium oxide nanoparticle | US2013337070A1 | Peter et al./ Peter et al | Coated nanoparticle therapy for skin cancer | In vivo | 2013 | [385] |
Silver-silverbromide-titanium dioxide nanoparticle | KR20130057744A | Woo et al./ Univ Soongsil Res Consortium | Composition for treating cancer containing Ag/AgBr/TiO2 nanoparticles that be activated under visible light | In vivo | 2013 | [386] |
Polymeric nanoparticle (Albumin)/ Bevacizumab | CA2917407A1 | Svetomir And Wendy/ Mayo Foundation | Complexes containing albumin-containing nanoparticles and antibodies to treat cancer | In vivo | 2014 | [387] |
Polymeric micelle/ Doxorubicin, Cisplatin | CN104784700A | Huayu et al. Changchun Applied Chemistry | Medicine co-carried compound, micelle and preparation method of micelle | In vitro | 2015 | [388] |
Niosome/ Doxorubicin | RU2600164C2 | Aleksandrovich | Doxorubicin and organosilicon nanoparticles-niosomes-based pharmaceutical gel for skin cancer treating | - | 2016 | [389] |
Carbon nanotube | WO2018008825A1 | Oh et al./ Korea Advanced Inst Sci & Tech | X-ray brachytherapy system for keloid and skin cancer treatment using carbon nanotube-based X-ray tube | - | 2018 | [390] |
Gold nanoparticle | US2019142980A1 | Angela et al./ Ricerche et al | Cells loaded with gold nanoparticles for use in the diagnosis and/or treatment of melanoma | In vivo | 2019 | [391] |
Silver prussian blue nanoparticle | US10231996B2 | Sudip and Ranjan/ Council Scient Ind Res | Biocampatible polymer coated silver prussian blue nanoparticles (SPB-NPs: Ag3[Fe(CN) 6]) | In vivo | 2019 | [392] |
Polymeric micelle | CN110339368A | Zhiyuan et al./ Univ Suzhou | Preparation method of reduction-response targeting polyethylene glycol-polycarbonate maytansine prodrug micelle | In vivo | 2019 | [393] |
Polymeric nanoparticle (Albumin)/ Paclitaxel, Trastuzumab | US10406224B2 | Svetomir And Wendy/ Mayo Found Medical Education & Res | Nanoparticle complexes of paclitaxel, trastuzumab, and albumin | In vivo | 2019 | [394] |
Carbonyl iron-sulfur cluster nanoparticle | CN111281858A | Hong et al./ Univ Shanghai | Application of carbonyl iron-sulfur cluster compound nanoparticles in drug preparation | In vivo | 2020 | [395] |
Polymeric nanoparticle (PLGA)/ Apatinib | CN111150718A | Ju et al./ Univ Qingdao | PLGA/poloxamer nanoparticles entrapping apatinib, production method and application | In vivo | 2020 | [396] |
Polymeric nanoparticle (Albumin)/ Paclitaxel, Bevacizumab | US10765741B2 | Svetomir And Wendy/ Mayo Found Medical Education & Res | Methods for treating VEGF-expressing cancer using preformed nanoparticle complexes comprising albumin-bound paclitaxel and bevacizumab | In vivo | 2020 | [397] |
Polymeric nanoparticle (DSPE-PEG2000)/ Temozolomide | CN111481526A | Guan et al./ Univ Xuzhou Medical | Cell-penetrating peptide modified drug-loaded thermosensitive nanoparticle and application thereof in resisting melanoma | In vitro | 2020 | [398] |
Liposome/ Catalase, anti-PDL1 | CN110974957A | Shichen et al./ Univ Beijing and Beijing Hongxin Stem Cell Biotechnology Co Ltd | Application of catalase-entrapped liposome connected with PD-L1 antibody in preparation of tumor treatment drugs | In vivo | 2020 | [399] |
Polymeric micelle/ Acetogenins | ES2826205A1 | Teresa et al./ Univ Cadiz | Procedure for obtaining a pharmaceutical composition using acetogenins with supramolecular polymeric micelles for the treatment of skin cancer | In vitro | 2021 | [400] |
Liposome/ Dacarbazine, Veirofenib (Vemurafenib) | CN113244174A | Qianqian et al./ Guangdong Laboratory of Southern Ocean Science and Eng Zhanjiang | Melanoma chemotherapy drug-loaded nano-liposome and preparation method thereof | In vitro | 2021 | [401] |
Liposome/ Doxorubicin, Trabectedin | WO2022115075A1 | Güliz and Şenay/ Ege Ueniversitesi | Targeted nanoparticles carrying dual drugs in the treatment of melanoma | In vivo | 2022 | [402] |
Gold nanoparticle/ Palladium nanoparticle/ Platinum nanoparticle/ Bimetallic gold–palladium nanoparticle/ Bimetallic gold-platinum nanoparticle | US2022218741A1 | Medina et al./ Univ Northeastern | Cell-mediated synthesis of noble metal oxide nanoparticles and biomedical applications thereof | In vitro | 2022 | [403] |
Polymeric nanoparticle (DSPE-PEG)/ Photothermal agent | WO2022134862A1 | Lei et al./ Univ South China Tech | Organic conjugated polymer photo-thermal reagent for treating malignant melanoma, nanoparticle, and preparation method therefor and use thereof | In vitro | 2022 | [404] |