Fig. 2
From: Circulating tumor nucleic acids: biology, release mechanisms, and clinical relevance
Heterogeneity of extracellular vesicles and lipoprotein complexes. Overlapping sizes and density hinder the separation and selective isolation of these components, and thus, their composition has yet to be fully described. A combination of multiple isolation techniques provides promising approaches for the comprehensive characterization of extracellular vesicles and lipoprotein complexes [99,100,101]