Fig. 4
From: Circulating tumor nucleic acids: biology, release mechanisms, and clinical relevance
Clinical utility of ctDNA in the context of disease evolution over time. The blue line depicts the level of ctDNA that carries a mutation detected in both the primary tumor and the blood. The yellow line shows the level of ctDNA representing a mutation that emerged with treatment resistance. MRD – minimal residual disease, WGS – whole genome sequencing, WES – whole exome sequencing, NGS – next generation sequencing, LOD – limit of detection, ddPCR – digital droplet PCR, qPCR – quantitative PCR)