Fig. 1
From: Targeting Pim kinases in hematological cancers: molecular and clinical review
Pim kinase expression during normal hematopoiesis. A Hierarchical differentiation trees for the expression of Pim-1, − 2, and − 3 during normal hematopoietic stem cell differentiation from the bone marrow (HSC-BM). Pim kinase expression levels are indicated by the legend, whereby the size and color of the nodes indicates general expression patterns. Data are derived from Normal human hematopoiesis (HemaExplorer) obtained from the BloodSpot Data base (https://servers.binf.ku.dk/bloodspot/) [11]. Definitions are as follows: CMP (Common myeloid progenitor cell), GMP (Granulocyte monocyte progenitors), MEP (Megakaryocyte-erythroid progenitor cell), NK cells (CD56+ natural killer cells), PM_BM (Promyelocyte from bone marrow), MY_BM (Myelocyte from bone marrow), PMN_BM (Polymorphonuclear cells from bone marrow), and PMN_PB (Polymorphonuclear cells from peripheral blood). B Pim-1, − 2, and − 3 expression patterns in blood samples. Graphs represent the normalized transcript expression values, denoted by average TPM (transcript per million). Data are derived from HPA (Human protein atlas) RNA-seq from the Human Protein Atlas database (https://www.proteinatlas.org/)