Fig. 2

Pan Cancer Analysis of Genetic Alterations in Pim kinases. A-D Results derived from the PanCancer Analysis of whole genomes (https://www.cbioportal.org/) for Pim-1, − 2, and − 3. Data encompasses whole genome sequencing from 2583 whole cancer genomes and matched normal tissue across 38 tumor types [28, 29]. A Oncoprint of genetic alterations in Pim kinases. Missense mutations (both putative drivers and unknown significance), splice and truncating mutations, amplification and deep deletions are shown. B The frequency of cancers harboring mutations, amplifications, and deep deletions in the Pim kinases are shown. C Mutations in Pim-1, − 2, and − 3 are demonstrated. Most mutations in Pim-1 are derived from samples with follicular lymphoma, nodal marginal zone lymphoma, and DLBCL. The position of the mutations in the Pim gene and the frequency of the mutation are shown. The most common mutation in each of the Pim genes is noted (Pim1: L184F/N, Pim2: P139A/Q), and Pim3: D305N). D Patient overall survival in individuals harboring Pim genetic alterations. Data represent 36 patients with alterations in Pim genes and 245 patients with unaltered Pim genes