Fig. 5
From: Targeting Pim kinases in hematological cancers: molecular and clinical review
Pim Kinase Expression and Genetic Alterations in Acute Myeloid Leukemia (AML) and Multiple Myeloma (MM). A and C Model depicting Pim kinase regulation in AML (A) and MM (C). Pim kinases are depicted in purple, with relative expression depicted by the size of the node. B and D Oncoprints of genetic alterations in AML (B) and MM (D) for Pim kinases derived from the cBioPortal from Cancer Genomics [29]. For (B), the results published are from whole genome sequencing and/or whole exome sequencing generated by OHSU Beat AML Project and the TCGA AML Project [77, 78]. The Beat project encompassed 672 AML patients with 454 matched, normal samples, while the TCGA project included 200 adult de novo AML tumor/normal pairs. D Data are derived from the cBioPortal for Cancer Genomics. Data sourced to whole exosome sequencing of 203 paired MM and normal patient samples [85]