Fig. 6
From: Targeting Pim kinases in hematological cancers: molecular and clinical review
Cellular Signaling Pathways and Genetic Alterations Leading to Pim Kinase Expression in Acute Lymphoblastic Leukemia (ALL). A Model depicting the regulation of Pim kinase expression and activity in ALL. IL-7 signaling leads to enhanced Pim-1 and Pim-2 expression. Alternatively, common genetic alterations found in ALL patients leads to enhanced JAK/STAT activity and up-regulation of Pim kinases. B-C Cancer type summary (B) and OncoPrint (C) of genetic alterations from 3 cancer genomic studies on ALL. Data are derived from the cBioPortal for Cancer Genomics [29, 30]. The results published here (ALL, Target-2018) are in whole or part based upon data generated by the Therapeutically Applicable Research to Generate Effective Treatments (TARGET) https://ocg.cancer.gov/programs/target initiative, phs000464 (Acute Lymphoblastic Leukemia (ALL) Expansion Phase 2). The data used for this analysis are available at https://portal.gdc.cancer.gov/projects. Target-2018 are derived from pediatric ALL. ALL-2016 are derived from 69, primarily children and young adult, B-progenitor ALL patient samples [103]. ALL-2015 are derived from 85 ALL infants with MLL rearrangements [104]