Fig. 8
From: Targeting Pim kinases in hematological cancers: molecular and clinical review
Cellular Mechanisms for Increased Pim Kinase Activity in Myeloproliferative Neoplasms. Model depicting the regulation of Pim kinase expression in various myeloproliferative neoplasms (MPNs). These include Polycythemia Vera (PV) blood cancer, Essential Thrombocythemia (ET) blood cancer, Myelofibrosis (MF) blood cancer, and Chronic Myelogenous Leukemia (CML). These cancers arise from mature hematopoietic cells in the lymph nodes. Pim kinases are activated through various mechanism, including genetic alterations JAK/STAT pathway and BRC/ABL mutations leading to downstream activation of Pim kinases