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Fig. 4 | Molecular Cancer

Fig. 4

From: CAR-cell therapy in the era of solid tumor treatment: current challenges and emerging therapeutic advances

Fig. 4

Possible combination therapies for CAR-M. CAR-M activation requires cancer cell recognition and interaction. Immune cell inhibitory mechanisms such as CD47/SIRPα or FcR/CD20 can limit CAR-M activity. CAR-M therapy demonstrated enhanced phagocytosis when combined with anti-CD47 and anti-HER2 (Trastuzumab) (A), with anti-CD47 and anti-CD20 (Rituximab) (B), as well as with anti-PD-1 (C). HER2; human epidermal growth factor receptor 2; PD-1; programmed cell death protein, SIRPα; signal regulatory protein α

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Molecular Cancer

ISSN: 1476-4598