Fig. 1

Genetic profiling of lung cancer (SCLC, LUAD, and LUSC) have shown changes in several oncogenes and tumor suppressor genes. Based on the total of somatic mutations, homozygous deletions, localized amplification, and substantial changes in gene expression, the values in each box represent the rates of genomic abnormalities. Other crucial proteins that mediate the pathways are also discussed. EGF, epidermal growth factor; FGF, fibroblast growth factor; GF, growth factor; DLL, deltalike; EGF, epidermal growth factor; FGF, fibroblast growth factor; GF, growth factor; HGF, hepatocyte growth factor; NRG, neuregulin; RTK, receptor tyrosine kinase. Figure reproduced with permission from Reference 39