Fig. 6
From: LncRNA-BC069792 suppresses tumor progression by targeting KCNQ4 in breast cancer
The downstream effector molecule regulated by KCNQ4 is JAK2/p-AKT. a After overexpression of BC069792, the mRNA expression of KCNQ4 was positively correlated with BC069792 and negatively correlated with JAK2. b After overexpression of BC069792, the protein expression of KCNQ4 was positively correlated with BC069792 and negatively correlated with JAK2. c In MDA-MB-231 (P = 0.0047) cell lines, overexpression of BC069792 reduced the expression of p-AKT protein. d In the BC069792 overexpression MDA-MB-231 cells, the protein content of KCNQ4 was significantly higher than that of p-AKT (P = 0.032), while the content of KCNQ4 and p-AKT in the pcDNA3.1 group was not statistically significant (P = 0.194). e In MDA-MB-231 cells, KCNQ4 was negatively correlated with p-AKT(r = -0.943, P = 0.017). f The expression of p-AKT protein in tumor tissue of nude mice was significantly different between LV-BC06972 group and LV-NC group, and it was highly expressed in LV-NC group(P = 0.001