Fig. 3
From: HOTAIR: a potential metastatic, drug-resistant and prognostic regulator of breast cancer
HOTAIR recruits EZH2 to the Myc promoter and facilitates the expression of Myc transcription factors. Myc binds to the gene promoter elements of DNA repair proteins Ku70/Ku80, DNA PKC, and ATM and promotes their expression to withstand the DNA damage caused by radiation in BC. b) miR 449b-5P suppresses radioresistance in BC by inhibiting the translation of HSPA1A. HOTAIR activates the translation and expression of HSPA1A by sponging miR-449b-5P. c) HOTAIR gene silencing and radiation therapy suppress miR-218, which in turn inhibits survivin, leading to DNA-damage dependent cell cycle arrest and apoptosis. d) HOTAIR activates AKP, which promotes proliferation and clonogenic survival via the activation of HOXD10