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Fig. 7 | Molecular Cancer

Fig. 7

From: A novel protein encoded by circINSIG1 reprograms cholesterol metabolism by promoting the ubiquitin-dependent degradation of INSIG1 in colorectal cancer

Fig. 7

circINSIG1 is a potential therapeutic target for CRC patients. A and B Growth curves and tumor weight of patient-derived xenograft (PDX) model tumors after treatment with shcircINSIG1 lentivirus (n = 5 per group). C H&E and Ki67 staining in PDX model tumors. Scale bar = 100 μm. D Western blot analysis of circINSIG1-121, INSIG1 and SREBP2(n) expression in the PDX tumors. GAPDH served as loading control. E and F qRT-PCR analysis of SREBP2 target genes expression in the PDX tumors. G Free cholesterol content detection in the PDX tumors. H A schematic model of circINSIG1 functions in tumor progression. Values are represented as mean ± SD. *p < 0.05, **p < 0.01, ***p < 0.001, by 2-tailed Student’s t test (A, B and G) and one-way ANOVA (E and F)

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Molecular Cancer

ISSN: 1476-4598