Table 1 Examples of antigens that are used as targets in particular cancer cells and their response to RT. Increase in antigen levels post RT follows with distinct timing and the effect lasts for several days up to one week

CT26 murine colon carcinoma cell line (in vitro)

75 Gy

Phosphatidylserine

Increase to 4% at 4 h and 10% at 24 h

Obeid et al., 2007 [52]

HT-29 human colon adenocarcinoma cell line (in vitro)

8 Gy*1, 2 Gy*4

Various (SILAC-based proteomic study after RT)

KPNA2, MART3, LCN2, OAT, TK1, HSPBL1, KRT20, KRT19 upregulated

(expression assessed at 24 h, 48 h, 72 h)

Song et al., 2016 [64]

Burkitt lymphoma cell lines Daudi and Raji (in vitro)

0.5–2.0 Gy

CD20

Increased expression within 24 h

Gupta et al., 2008 [65]

Neoplastic B-cell lines (IM9, IM9/Bcl2, Ramos) (in vitro)

5,10,15,20, 20 Gy

CD20

Dose-dependent upregulation up to 10 Gy, peaking at 24 h and disappearing at 48 h

Kunala and Macklis, 2001 [66]

HT-29 human colon adenocarcinoma cell line (in vitro)

6 Gy

MUC1

Two-fold increase from day 1 after RT, continuation of increase up to day 4

Kang et al., 2000 [67]

MKN45 gastric adenocarcinoma cell line (in vitro)

5-15 Gy

CEA

Increased surface expression 4 days after RT in a dose-dependent manner

Hareyama et al., 1988 [68]

CT26 murine colon carcinoma cell line (in vivo)

2 Gy*5

PD-L1

Increased expression within one week, effect away after day 7

Dovedi et al., 2014 [69]