Fig. 1

Molecular mimicry: homology in the TCR facing residues and molecular interaction. The MAGE-A1_{278 − 286} peptide and the homologous peptide derived from Faecalibacterium prausnitzii (WP_158387495.1) are shown bound to the HLA-A*02:01 molecule. The identical residues K₁, E₄, Y₅, I₇ are presented to the TCR αβ chains with the same conformation (A – D). The contact areas in red between the two peptides and the TCR αβ chains are identical (E - H). The areas of contact between the HLA molecule and the TCR αβ chains are identical (yellow and dark blue areas) (I, J)