Table 1 Examples of homologies between tumor-associate antigens (TAAs) and viral antigens
HOMOLOGY BETWEEN TAAs AND VIRAL ANTIGENS | |||||||
|---|---|---|---|---|---|---|---|
CANCER TYPE | TAA | MoA | HLA | Evidence | Reference | ||
Melanoma | MART-127−35 | AAGIGILTV | HSV-1 | GIGIGVLAA | A*02:01 | Cross-reactive CTL in melanoma patients | [39] |
MART-126−35 | EAAGIGILTV | Pseudorabies virus | VIAGIGILAI | A*02:01 | Cross-reactive CTL in melanoma patients | ||
Variola virus | MIAGIGISLI | A*02:01 | |||||
Lung ca. | TMEM161A | ALGGLLTPL | EBV | CLGGLLTMV | A*02:01 | Cross-reactive CTL in lung cancer patients | [43] |
Melanoma | Gp100 | MLGTHTMEV | HCMV | MLGTHAMLV | A*02:01 | Cross-reactive T cells in ex vivo experiments | [48] |
Multiple ca. | CD274 | LLNAFTVTV | HIV-1 | LLNAFAIAV | A*02:01 | ||
Liver ca. | HEPACAM | RLAPFVYLL | Encephal. virus | RLAPFGYKI | A*02:01 | ||
Gut ca. | CEA | IMIGVLVGV | HIV-1 | IMVGALIGV | A*02:01 | ||
Multiple ca. | TELOMERASE | RLVDDFLLV | HIV-1 | RLVDEFLAI | A*02:01 | ||
Liver ca. | ISG15 | MLAGNEFQV | Calicivirus | MLAGNAFTA | A*02:01 | Cross-reactive T cells in ex vivo experiments | [49] |
MDK | ALLALTSAV | HCV | ALMAFTSAV | A*02:01 | |||
MDK | LLLTLLALL | Adenovirus | LLLTLLLLL | A*02:01 | |||
C1QTNF12 | LLGPQLVLL | HBV | LLGPLLVLL | A*02:01 | |||
Breast ca. | CCR9 | AIADLLFLV | HIV-1 | RLRDLLFLV | A*02:01 | Cross-reactive T cells in ex vivo experiments | [50] |
Colon ca. | EPCAM | VVAGIVVLV | VVAGIIALV | A*02:01 | |||
Brain ca. | DPYSL2 | IPRRTTQRI | IPRRIRQRI | B*07:02 | |||
Lung ca. | CNIH4 | LLNLPVATW | HCNLSVATW | B*58:01 | |||
Prostate ca. | NDUFS2 | VSDGSSRPY | SSDNSSRPY | A*01:01 | |||