Table 2 Examples of homologies between tumor-associate antigens (TAAs) and bacterial antigens
HOMOLOGY BETWEEN TAAs AND BACTERIAL ANTIGENS | |||||||
|---|---|---|---|---|---|---|---|
CANCER TYPE | TAA | MoA | HLA | Evidence | Reference | ||
Melanoma | MART-127−35 | AAGIGILTV | Bacillus polymyxa | GAGIGVLTA | A*02:01 | Cross-reactive CTL in melanoma patients | [39] |
E. coli | QAGIGILLA | A*02:01 | |||||
MART-126−35 | EAAGIGILTV | Chl. trachomatis | MLSGIGIFFI | A*02:01 | Cross-reactive CTL in melanoma patients | [41] | |
MAGE-A6172 − 187 | YIFATCLGLS | Myc. penetrans | YIFAACLLLI | A*02:01 | Cross-reactive CTL in melanoma patients | [51] | |
Multiple ca. | MAGE-A10 | GLYDGMEHL | Cohnella nanjingensis | GLYDGVEHV | A*02:01 | Bioinformatics analyses | [53] |
Chitinophagaceae bacterium | GMYDGLEHV | A*02:01 | |||||
MAGE-A3 | KVAELVHFL | Sedimentibacter sp. | KIAELVHFL | A*02:01 | |||
Solirubrum puertoriconensis | KVAELVHHV | A*02:01 | |||||
MAGE-A1 | KVLEYVIKV | Firmicutes bacterium | KVLEYVIRV | A*02:01 | |||
Candidatus Faecivivens stercorigallinarum | KVLEYLPKV | A*02:01 | |||||
MAGE-C2 | ALKDVEERV | Loigolactobacillus jiayinensis | ALSDVEERV | A*02:01 | |||
Lachnospiraceae bacterium MD329 | ALNDVEERL | A*02:01 | |||||
MAGE-A12 | FLWGPRALV | Bacteroidales bacterium | FLWGSIALV | A*02:01 | |||
Clostridia bacterium | FLWGPFSLV | A*02:01 | |||||
SSX-2 | KASEKIFYV | Lachnospiraceae bacterium | KAAEKFFYV | A*02:01 | |||
Agathobacter sp. | KASDKIFYV | A*02:01 | |||||
MAGE-C1 | KVVEFLAML | Clostridia bacterium | KILEFLAML | A*02:01 | |||
Clostridia bacterium | KVVEFLAML | A*02:01 | |||||