Fig. 3
From: The role of m6A methylation in therapy resistance in cancer
The process of m6A methylation
The “writers” add methyl groups to RNA. METTL3 and METTL14 have a substrate recognition function. WTAP is responsible for recruiting METTL3, METTL14 and other components. The m6A modification is removed by “erasers” (FTO and ALKBH5). The “readers” recognize m6A and affect various functions of RNA, and they mainly include members of the YTH domain-containing family (YTHDC1/2 and YTHDF1/2) which can degrade mRNA.