Fig. 4

The role of m6A methylation in therapy resistance

The m6A regulators promote tumor cell resistance to radiation via stabilizing mRNA, regulating HR and inhibiting signaling pathway. The m6A regulators promote the stability of target gene mRNA and affect the recruitment of immune cell and the secretion of cytokines. The various pathway of m6A regulators in the resistance to chemical drugs (Cisplatin, Gemcitabine, Kinase inhibitor). The red arrows indicate “promote” and the blue arrows indicate “inhibit”