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Fig. 3 | Molecular Cancer

Fig. 3

From: A combined computational and functional approach identifies IGF2BP2 as a driver of chemoresistance in a wide array of pre-clinical models of colorectal cancer

Fig. 3

IGF2BP2 expression is associated with chemoresistance in PDOs and in PDXs. A Table shows Pearson correlation coefficients (R2) and respective p-values for correlation analysis of IGF2BP2 expression of primary tumor tissues with logIC50 values of the respective drug in the matched PDOs. IC50 values have previously been published [31]. Significant correlations are depicted by grey background color. B PDX samples of primary tumor and liver metastasis tissue (n = 52) were divided in high (above median) and low (below median) IGF2BP2 expressing groups. PDX tumor growth under treatment with the respective drug was plotted. Statistical significance was determined by Mann-Whitney U Test for not normally distributed samples or Student´s t-test for normally distributed samples

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Molecular Cancer

ISSN: 1476-4598