Fig. 4
SX-682 affects BrafV600E/Pten−/− and NRasQ61R/Ink4a−/− tumorigenesis. a BrafV600E/Pten−/− and b NRasQ61R/Ink4a−/− mice were fed chow containing SX-682 or vehicle continuously through tumor formation, and tumors were measured and counted. Significance was determined using a Welch's t-test. c A volcano plot showing fold change and significance of differential gene expression between tumors from SX-682-fed and control-fed BrafV600E/Pten−/− mice. d Gene set enrichment analysis of SX-682 treated or control BrafV600E/Pten.−/− tumors identifies gene sets enriched in SX-682 treated tumors (positive normalized enrichment score) or enriched in control tumors (negative normalized enrichment score)