Fig. 6

Tumor cell-specific impacts of SX-682. CXCL1 and CXCR2 expression on Melan-A, B16F0, and B16F10 cells based on a the NCBI database and b CXCR2 expression in Melan-A, B16F0 and B16F10 cells based on flow cytometry. c Cell lines were treated with 5 µM SX-682 (or DMSO control) for 4 days prior to staining with Pacific Blue-Ki67 for FACS analysis. The percentage of positive staining cells was significantly decreased in the SX-682 treated cells for all cell lines (analyzed using a two-way ANOVA with Benjamini and Hochberg (BH) correction for multiple tests). d Cytokine array of SX-682-treated Melan-A, B16F0 and B16F10 cells shows that SX-682 treatment reduced the expression of KC and VEGF in all three cell lines