Fig. 7

Tfcp2l1 is commonly upregulated across three models of CXCR2 perturbation. a, b In comparing expression data from Braf^V600E/Pten^−/−/Cxcr2^−/− tumors. Braf^V600E/Pten^−/− tumors treated with SX-682, and B16F0 and B16F10 cell lines treated with SX-682, Tfcp2l1 was consistently upregulated compared to appropriate controls (as determined by Welch's t-test). c Log₂ fold change for Tfcp2l1 and related genes across experimental groups based upon RNAseq analysis. d Identification of transcription factors central to Weighted Correlation Network Analysis (WGCNA) co-expressed gene modules (by kME) and significantly differentially expressed between Braf^V600E/Pten^−/−/Cxcr2^−/− and Braf^V600E/Pten^−/−/Cxcr2^WT tumors. TFs are colored by gene module and show varying levels of centrality to each module and importance in distinguishing WT and KO tumors. Turquoise dots represent transcription factors that are up in the Braf^V600E/Pten^−/−/Cxcr2^−/− tumors and blue dots represent transcription factors that are up in the Braf^V600E/Pten^−/−/Cxcr2^WT tumors