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Fig. 1 | Molecular Cancer

Fig. 1

From: IGF2BP1 induces neuroblastoma via a druggable feedforward loop with MYCN promoting 17q oncogene expression

Fig. 1

Unbalanced Chromosome 17q upregulates MNA neuroblastoma essential genes and indicates adverse disease outcome. a Frequency (%) of DNA copy number gains (red) and losses (blue) for chromosome 1 to 22 in 100 primary human neuroblastoma samples. b, c Kaplan–Meier survival analyses by Chr 17q balance status (b, left), MYCN amplification status in Chr 17q unbalanced tumors (b, right) and MYCN amplification status (c). d Genomic distribution of 175 autosomal essential genes in MNA neuroblastoma. e Genomic location and percentage gain of essential (black and IGF2BP1 in blue) neuroblastoma genes on Chr 17 in primary neuroblastoma (non-essential TP53 on 17p is highlighted red). f Kaplan–Meier survival analyses by IGF2BP1 mRNA expression (best cut-off)

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Molecular Cancer

ISSN: 1476-4598