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Table 3 Hypergeometric testing for distribution of neuroblastoma essential genes

From: IGF2BP1 induces neuroblastoma via a druggable feedforward loop with MYCN promoting 17q oncogene expression

Chr

protein coding genes

NB essential genes

% distribution

p-value

1

2048

22

12.6%

0.2496822

2

1247

17

9.7%

0.0668034

3

1075

4

2.3%

0.9904822

4

751

5

2.9%

0.8245106

5

886

4

2.3%

0.9651801

6

1047

6

3.4%

0.9238733

7

917

4

2.3%

0.9716455

8

683

3

1.7%

0.9527968

9

781

5

2.9%

0.8492704

10

731

4

2.3%

0.9076264

11

1311

6

3.4%

0.9835301

12

1035

10

5.7%

0.4815816

13

321

3

1.7%

0.5682151

14

612

0

0.0%

1

15

599

7

4.0%

0.3128974

16

853

5

2.9%

0.8971414

17

1188

52

29.7%

5.047e-22

18

268

3

1.7%

0.4479059

19

1471

9

5.1%

0.9305177

20

546

2

1.1%

0.9626367

21

232

0

0.0%

1

22

444

4

2.3%

0.5853077

  1. Chr Chromosome; NB Neuroblastoma