Table 6 Validated and predicted miRNA-binding sites for MYCN
miRNA family | miRNA binding | binding site (MYCN 3´UTR bp) | luciferase reporter |
|---|---|---|---|
miR-34-5p | validated | 22–29 | mutated |
miR-19-3p | validated | 31–38 | mutated |
miR-29-3p | validated | 332–339 | mutated |
miR-101-3p | validated | 493–500 | mutated |
let-7-5p/miR-98-5p | validated | 505–511 | mutated |
miR-101-3p | validated | 562–568 | wildtype |
miR-34-5p | validated | 579–585 | mutated |
miR-302-3p | predicted | 858–864 | mutated |
miR-17-5p/20-5p/93-5p/106-5p | predicted | 859–865 | mutated |
let-7-5p/miR-98-5p | validated | 868–874 | mutated |