Table 2 Anti-TIGIT antibody drugs in clinical development
From: Co-inhibition of TIGIT and PD-1/PD-L1 in Cancer Immunotherapy: Mechanisms and Clinical Trials
Drug | Mechanism of action | Sponsor |
|---|---|---|
AZD2936 | A bispecific antibody that can target both PD-1 and TIGIT simultaneously | AstraZeneca |
HLX301 | A bispecific antibody that can target both PD-1 and TIGIT simultaneously | Henlius |
HB0036 | A bispecific antibody that can target both PD-1 and TIGIT simultaneously | Huaota |
IBI321 | A bispecific antibody that can target both PD-1 and TIGIT simultaneously | Innovent Biologics |
MK-7684Â A | A fixed-dose combination formulation composed of Vibostolimab and Pembrolizumab | Merck |
Domvanalimab | A Fc-silent humanized IgG1 monoclonal antibody directed against TIGIT | Arcus Biosciences |
BMS-986,207 | Â A Fc-silent humanized IgG1 monoclonal antibody directed against TIGIT | Bristol Myers Squibb |
BAT6021 | An investigational humanized IgG1 monoclonal antibody directed against TIGIT | Bio-thera |
PM1021 | An investigational humanized IgG1 monoclonal antibody directed against TIGIT | Biotheus |
M6223 | An investigational humanized IgG1 monoclonal antibody directed against TIGIT | EMD Serono |
EOS-448 | An investigational humanized IgG1 monoclonal antibody directed against TIGIT | iTeos |
Vibostolimab | An investigational humanized IgG1 monoclonal antibody directed against TIGIT | Merck |
Etigilimab | An investigational humanized IgG1 monoclonal antibody directed against TIGIT | Mereo |
Tiragolumab | An investigational humanized IgG1 monoclonal antibody directed against TIGIT | Roche |
Ociperlimab | An investigational humanized IgG1 monoclonal antibody directed against TIGIT | BeiGene |
ASP8374 | An investigational humanized IgG4 monoclonal antibody directed against TIGIT | Astellas |
COM902 | An investigational humanized IgG4 monoclonal antibody directed against TIGIT | Compugen |
IBI939 | An investigational humanized IgG4κ monoclonal antibody directed against TIGIT | Innovent Biologics |
JS006 | An investigational humanized IgG4κ monoclonal antibody directed against TIGIT | Junshi |
SEA-TGT | A nonfucosylated antibody that employs sugar engineered antibody against TIGIT | Seagen Inc |
AB308 | An investigational humanized IgG1 monoclonal antibody directed against TIGIT | Arcus Biosciences |