Fig. 2From: CircXRN2 suppresses tumor progression driven by histone lactylation through activating the Hippo pathway in human bladder cancerCircXRN2 inhibits the proliferation and migration of bladder cancer cells in vitro and in vivo. a A CCK-8 assay was conducted to evaluate cell viability in control and circXRN2-overexpressing cells. b CircXRN2 suppressed the colony-formation ability of bladder cancer cells. c CircXRN2-induced cell apoptosis in T24 and EJ cells. d, e Transwell migration assays and wound healing assays were conducted to evaluate cell migratory abilities. f Schematic illustration of the subcutaneous tumorigenesis model in nude mice with negative control or circXRN2-overexpressing cells. g-i CircXRN2 inhibited tumor growth of human bladder cancer in vivo (n = 5). j Schematic illustration of the lung metastatic model in nude mice with negative control or circXRN2-overexpressing cells. k-l Overexpressing circXRN2 led to fewer lung metastatic nodules than in the control group. All the data are presented as the mean ± standard deviation (n = 5). *P < 0.05, **P < 0.01, compared with the control groupBack to article page