Table 5 Future directions for CRISPR-based cancer therapy
Research Priorities | Emerging Technologies | Translational Opportunities | Collaborative Efforts | Societal Impact | Ref |
|---|---|---|---|---|---|
Development of more precise and efficient delivery systems | Expansion of genome editing tools beyond gene knockout and correction | Development of biomarkers to predict treatment response | Collaborative development of ethical guidelines for CRISPR-based therapy | Equitable access to CRISPR-based cancer therapy | [268] |
Development of gene editing tools to target non-coding regions of the genome | Application of CRISPR screens to identify new therapeutic targets | Use of gene editing to improve immunotherapy response | Collaboration between academic institutions and industry to accelerate drug development | Impacts on healthcare economics and resource allocation | [269] |
Exploration of combination therapies that include CRISPR-based interventions | Integration of CRISPR technology with emerging imaging and sensing technologies | Application of CRISPR gene editing to develop personalized cancer vaccines | Collaborative development of CRISPR-based diagnostic tools | Ethical implications of germline editing for cancer prevention and treatment | [271] |
Developing new approaches to improve specificity of CRISPR-Cas9 gene editing | Exploring the use of CRISPR gene regulation to modulate gene expression | Testing the efficacy of CRISPR-based cancer therapy in combination with other standard therapies | Development of international regulatory frameworks for gene editing technology | Education and public outreach to promote understanding and acceptance of gene editing technology | [272] |
Studying the impact of CRISPR gene editing on tumor microenvironment and the immune system | Developing CRISPR-based tools for non-invasive cancer detection and monitoring | Incorporating CRISPR gene editing into patient stratification and clinical trial design | Collaboration among researchers to advance the understanding of CRISPR mechanisms and their role in cancer biology | Addressing issues of genetic discrimination and privacy concerns related to gene editing technology | [18] |
Designing CRISPR gene editing systems for the treatment of rare or difficult-to-treat cancers | Advancing gene editing technology to target complex genetic abnormalities in cancer cells | Establishing international databases to promote sharing of CRISPR-based therapy data and protocols | Development of guidelines and standards for quality control and product safety for CRISPR-based therapies | Ensuring equitable access to CRISPR-based cancer therapy in diverse patient populations | [270] |
Developing gene editing strategies to overcome resistance to standard cancer therapies | Integration of CRISPR technology with nanotechnology for enhanced delivery and targeting of cancer cells | Establishing public–private partnerships to accelerate the development of CRISPR-based cancer therapies | Collaboration between clinicians and basic researchers to optimize the design and delivery of CRISPR-based cancer therapies | Evaluation of the long-term safety and efficacy of CRISPR-based cancer therapy |